A study to find which method gives better pain relief in patients undergoing liver,gall bladder and pancreas surgery — a single pain injection near the spinal cord or continuous pain medicine through a small tube placed around the spinal nerves(epidural space).”

Comparative study of intrathecal morphine versus thoracic epidural for post operative analgesia in patients undergoing hepato pancreato biliary surgery : A Randomised Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/096974

Enrollment

Registered

2025-11-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Single shot intrathecal morphine: Patients in this group will receive intrathecal injection of morphine before induction at L3-L4 or L4-L5 space using a dose of 5micrograms/kg as 0.5ml

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing Elective hepato-pancreato-biliary surgery American Society of Anaesthesiologists status I, II, III. BMI – 18-24kg/m2

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to neuraxial anesthesia (e.g., coagulopathy, infection at injection site, severe spine deformity, known allergy or hypersensitivity). 2. Chronic opioid use or opioid dependence prior to surgery. 3. Patients who couldn’t understand the technique of operating the PCA pump 4. Patients who are not extubated within 48hours after surgery

Design outcomes

Primary

Measure	Time frame
To evaluate total opioid consumption over 48 hours postoperatively in adult patients undergoing hepatopancreatobiliary surgeries, comparing those receiving intrathecal morphine with those receiving thoracic epidural analgesia.Timepoint: Total opioid consumption after 48 hours	—

Secondary

Measure	Time frame
To evaluate the incidence of analgesia-related complications such as hypotension, vomiting, respiratory depression among both groups Timepoint: Within first 7 days after surgery;To assess time to first rescue analgesia among both groups Timepoint: In the post operative period;To compare peri-operative fluid use among both groups Timepoint: Within the first 48 hours of surgery;To compare the length of hospital stay among both groupsTimepoint: Till the patient is discharged from the hospital	—

Measure

Time frame

To evaluate the incidence of analgesia-related complications such as hypotension, vomiting, respiratory depression among both groups Timepoint: Within first 7 days after surgery;To assess time to first rescue analgesia among both groups Timepoint: In the post operative period;To compare peri-operative fluid use among both groups Timepoint: Within the first 48 hours of surgery;To compare the length of hospital stay among both groupsTimepoint: Till the patient is discharged from the hospital

—

Countries

India

Contacts

Public ContactDr Santosh

AIIMS Patna

drshaguftanaaz@gmail.com7765937919

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026