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A study to compare the tooth forming ability of stem cells in 2D and 3D culture system

Comparative analysis of Odonto/Osteogenic Potential of human gingival mesenchymal stem cells in 2D and 3D culture systems - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/096955
Enrollment
5
Registered
2025-11-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil Intervention6: Nil: Nil Intervention7: Nil: Nil Intervention8: Nil: Nil Interven

Sponsors

A B Shetty Memorial Institute of Dental sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy patients with a minimum complement of 20 natural teeth undergoing extraction of premolars for orthodontic treatment. 2.Patients with good oral hygiene (Plaque index less than 1). 3.Periodontally healthy patients (less than 1 Gingival index score, less than 3 mm PD and CAL less than 2 mm). 4.Age group between 18 and 30 years.

Exclusion criteria

Exclusion criteria: 1.Patients with history of any systemic disease. 2.Patients on antibiotic therapy of any form for the last 6 months. 3.Presence of any periodontal disease. 4.History of any form of tobacco usage. 5.Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
The present study compares odontogenic and osteogenic differentiation potential of human gingival mesenchymal stem cells when cultured under 2d and 3d culture systems. The finding of this study will contribute to better understanding of regenerative potential of gingival stem cells and aid in developing scaffold based strategies for periodontal regenerationTimepoint: 4 weeks to 8 weeks—

Secondary

MeasureTime frame
nilTimepoint: nil—

Countries

India

Contacts

Public ContactSrilakshmi

NITTE (Deemed to be University)

drmamathasshetty@nitte.edu.in9886756440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026