Comparing pain relief of drugs like Dexmedetomidine vs Buprenorphine vs Dexamethasone in patients undergoing abdominal surgeries

A double blinded randomized controlled study comparing analgesic efficacy of Dexmedetomidine versus Buprenorphine versus Dexamethasone as an adjuvant to Bupivacaine in ultrasound guided combined tranversus abdominis plane block and rectus sheath block for postoperative pain relief in patients undergoing abdominal surgeries - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/096954

Enrollment

Registered

2025-11-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K819- Cholecystitis, unspecified Health Condition 2: N858- Other specified noninflammatory disorders of uterus Health Condition 3: K429- Umbilical hernia without obstruction or gangrene

Interventions

Intervention1: Group A: Dexmedetomidine + 0.125% Bupivacaine Using 1 microgam/kilogram of dexmedetomidine as an adjuvant to 0.125% concentration local bupivacaine in given combined ultrasound guided

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE 1 and 2 patients. Patients undergoing elective abdominal surgeries. Patients giving written informed consent.

Exclusion criteria

Exclusion criteria: Age less than 18 years, Age greater than 65 years. No genders are excluded. Patient refusal to participate in the study. Any contraindication to regional anaesthesia. Patients with neurological or psychiatric problems. Patient allergic to study drugs. Patients with uncontrolled hypertension or bradycardia. Patients on chronic opioid therapy and other pain medications. ASA GRADES 3 and above.

Design outcomes

Primary

Measure	Time frame
To compare the postoperative analgesic efficacy of dexmedetomidine versus buprenorphine versus dexamethasone in combined transversus abdominis plane block and rectus sheath block in abdominal surgeries in providing postoperative analgesia as measured by visual analogue scale and numeric rating scale at specific time intervals.Timepoint: 30 minutes 2 hours 4 hours 6 hours 10 hours 16 hours 24 hours	—

Measure

Time frame

To compare the postoperative analgesic efficacy of dexmedetomidine versus buprenorphine versus dexamethasone in combined transversus abdominis plane block and rectus sheath block in abdominal surgeries in providing postoperative analgesia as measured by visual analogue scale and numeric rating scale at specific time intervals.Timepoint: 30 minutes 2 hours 4 hours 6 hours 10 hours 16 hours 24 hours

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Secondary

Measure	Time frame
To evaluate duration of analgesia in hours provided by each drug by assessing the time until the first dose of rescue analgesic is required postoperatively.Timepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS;To compare the total amount of rescue analgesic administered in the first 24 hours post surgery among the 3 groups.Timepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS;To assess the incidence of postoperative complicationsTimepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS	—

Measure

Time frame

To evaluate duration of analgesia in hours provided by each drug by assessing the time until the first dose of rescue analgesic is required postoperatively.Timepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS;To compare the total amount of rescue analgesic administered in the first 24 hours post surgery among the 3 groups.Timepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS;To assess the incidence of postoperative complicationsTimepoint: 30 MINUTES 2 HOURS 4 HOURS 6 HOURS 10 HOURS 16 HOURS 24 HOURS

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Countries

India

Contacts

Public ContactManfred Francis Cardozo

Seth V.C Gandhi and M.A Vora Municipal General Hospital

reenanebu@rediff.com9820024211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026