Skip to content

Multimodal Intervention in Children with Autism Spectrum Disorder

Effectiveness of a Five-Component Multimodal Intervention on Executive Function in Children with Autism Spectrum Disorder: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/096943
Enrollment
195
Registered
2025-11-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F840- Autistic disorder

Interventions

Intervention1: Experimental group: The intervention will consist of a 12-week small-group structured exercise program, conducted five times per week for 60 minutes per session. Each participant will a
15 minutes of aerobic activity to improve cardiovascular fitness and mood stability
10 minutes of strengthening exercises targeting major muscle groups
15 minutes of neurocognitive tasks promoting attention and executive functioning
and 10 minutes of music-based mindfulness to support relaxation and social interaction. The program will progressively adapt to individual ability levels to ensure safety, engagement, and sustainable

Sponsors

Kazi Md Azman Hossain
Lead Sponsor
Jashore University of Science and Technology JUST
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Participants will be included if aged between 4 and 18 years, including both boys and girls, who will have been diagnosed with Autism Spectrum Disorder (ASD) in accordance with the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), based on clinical assessment and confirmed by evaluation using the Childhood Autism Rating Scale, Second Edition (CARS-2), conducted by a child psychiatrist. Consent to participate in a 12-week intervention period.

Exclusion criteria

Exclusion criteria: Participants will be excluded if they have cerebral palsy, Down syndrome, or attention deficit/hyperactivity disorder (ADHD). Additionally, any participant who reports, or whose parent reports, a recent (within the past six months) muscle injury or other conditions—such as muscle sprain, head injury, or skin laceration—that may interfere with study outcomes or exercise participation will also be excluded.

Design outcomes

Primary

MeasureTime frame
Executive Function: Inhibitory Control (IC) - Go/No-go (GNG) task; Cognitive Flexibility (CF) - Trail Making Test A–B; Working Memory (WM) - Corsi block tapping task (CBTT), Forward digit span test (FDS), and Backward digit span test (BDS).Timepoint: At baseline, week-12, and week-24

Secondary

MeasureTime frame
Social Responsiveness Scales Second Edition (SRS-2), Autism Treatment Evaluation Checklist (ATEC)Timepoint: At baseline, week-12, and week-24

Countries

Bangladesh

Contacts

Public ContactKazi Md Azman Hossain

Jashore University of Science and Technology (JUST)

azmanhossain51@gmail.com01660140833

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 28, 2026