Health Condition 1: L814- Other melanin hyperpigmentation
Conditions
Interventions
Intervention1: Picosecond Nd:YAG (PSNY): On split-face Side A, Picosecond Nd:YAG (PSNY) laser toning monotherapy will be performed using a full-spot handpiece in non-contact mode, maintaining a 1–2 cm
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Male or female adult patients aged 18-85 years with Fitzpatrick skin types III-V affected by any type of facial melasma (epidermal, dermal, mixed, centrofacial, malar, or mandibular type).
Exclusion criteria
Exclusion criteria: 1.Photosensitivity 2.Active infection on the face 3.History of cutaneous malignancy 4.Immunosuppressed state 5.Use of topical retinoids within the previous 12 months 6.Laser procedure, peel, or dermabrasion within the previous 3 months 7.Use of topical lightening creams in the treatment area within the past 1 month 8.Pregnant or lactating 9.Unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the change in the Hemifacial-Modified Melasma Area and Severity Index (Hemi-mMASI) score from baseline to post-treatment follow-up.Timepoint: After 20months | — |
Secondary
| Measure | Time frame |
|---|---|
| compare clinical improvement in facial melasma using standardized photographs and evaluate pigment dilution through QuantifiCare LifeViz® Mini 3D imaging at baseline and at the end of the study (week 8). Changes in dermoscopic pigmentary and vascular component scores, patient satisfaction with the combined laser therapy, and any treatment-related adverse effects will also be assessed at every visitTimepoint: After 2 months | — |
Countries
India
Contacts
Public ContactDr Chaithra Shenoy
CUTIS Academy of Cutaneous Sciences
Outcome results
None listed