Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: extended letrozole regimen: Letrozole resistance is defined as the lack of follicular development beyond 10mm on the day 10 ultrasound scan among patients who underwent standard LE ther
Sponsors
KIMS Foundation and Research Center
Eligibility
Inclusion criteria
Inclusion criteria: • Women aged between 21 to 40 years with Body Mass Index (BMI) ranging from 19 to 35 kg/m². • Treatment naïve patients • Women who underwent ovulation induction elsewhere Letrozole resistance is defined as the lack of follicular development beyond 10mm on the day 10 ultrasound scan among patients who underwent standard LE therapy 5 mg for 5 days. These patients will be randomised after the day 9 scan to either extended letrozole or gonadotrophins for follicular development.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare and evaluate the ovulation rate confirmed by ultrasound in both the arms. Timepoint: 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the number of follicles greater than or equal to 14 mm of the day of the trigger.Timepoint: on day 25;pregnancy rate confirmed by urine pregnancy test or beta HCGTimepoint: two weeks after ovulatation;To assess the incidence of multiple pregnancies and ovarian hyperstimulationTimepoint: Follow up period | — |
Countries
India
Contacts
Public ContactVyjayanthi Srinivasan
Krishna Institute of Medical Sciences
Outcome results
None listed