A clinical trial to study the effect of two drugs,sugammadex and neostigmine reversals in preventing the lung complications after surgery in COPD patients.

Comparative evaluation of Sugammadex and Neostigmine reversals in preventing post-operative pulmonary complications in chronic obstuctive pulmonary disease - A Prospective , Randomized , Double blinded study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096724

Enrollment

Registered

2025-10-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Neostigmine: Neostigmine (50mcg/kg) mixed with Glycopyrrolate (10mcg/kg) at the end of surgery for reversal from general anaesthesia Control Intervention1: Sugammadex: Sugammadex (2mg/k

Eligibility

Inclusion criteria

Inclusion criteria: BMI 18-25kg/m2 , Patients scheduled for elective laparoscopic abdominal surgeries

Exclusion criteria

Exclusion criteria: History of allergy to the study drugs , Chronic renal disease patients ( creatinine clearance lesser than 30ml/min) , Patients with other co existing pulmonary diseases, Patients with severe coronary artery insufficiency and other fixed cardiac output states, Emergency surgeries , Moribund patients

Design outcomes

Primary

Measure	Time frame
Measurement of peak expiratory flow rate in both the groups in the preoperative period and at varied time intervals post operativelyTimepoint: Baseline peak expiratory flow rate value preoperatively , immediately following extubation , in hours till 6 hours post procedure then at 24 hours interval till post operative day 3	—

Secondary

Measure	Time frame
Evaluate the incidence of post operative pulmonary complications(PPC) like COPD exacerbation, inability to clear secretions, bronchospasm and respiratory failure in both the groups measured upto 3 days after the surgeryTimepoint: Immediately following extubation , in hours till 6 hours post procedure then at 24 hours interval till post operative day 3	—

Countries

India

Contacts

Public ContactS Sevukar Raja

Bhaarath Medical College and Hospital

drsevukar@live.in9500976956

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026