Health Condition 1: - Health Condition 2: K801- Calculus of gallbladder with othercholecystitis
Conditions
Interventions
Intervention1: Inj. Sugammadex 2mg/kg: Study participants will receive Inj. Sugammadex 2mg/kg diluted in 10mL normal saline for reversal of vecuronium induced neuromuscular blockade when four twitches
Sponsors
Regional Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients of either sex-male or female 2. Patients of age group 18 to 60 years of Manipuri ethnicity undergoing elective laparoscopic cholecystectomy surgery under general anaesthesia. 3. Patients of American Society of Anesthesiologists (ASA) physical status grade I or II
Exclusion criteria
Exclusion criteria: 1. Patients not willing to participate 2. Patients with known allergy to any of the study drugs 3. Patients with known neuromuscular disease. 4. Patients with pre-existing respiratory, cardiovascular, hepatic or renal dysfunction. 5. Patients with suspected malignant hyperthermia 6. Pregnant and breastfeeding patients 7. Patient who had joined in any studies in the past one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Time taken from the start of administration of the study drugs (Sugammadex or Neostigmine-Glycopyrrolate) at appearance of fourth twitch of train of four stimulation till recovery of normalized TOF ratio of 0.9 or more. 2. Time to 5 secs head lift from the time of administration of the study drugs.Timepoint: 1. Time (mins) taken from the start of administration of the study drugs (Sugammadex or Neostigmine-Glycopyrrolate) at appearance of fourth twitch of train of four stimulation till recovery of normalized TOF ratio of 0.9 or more( single time point) 2. Time (mins) to 5 secs head lift from the start of administration of the study drugs( single time point). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hemodynamic parameters such as blood pressure(BP) & heart rate (HR). 2. Incidences of train of four normalized ratio of less than 0.9 during the first hour of post-operative period.Timepoint: 1.Hemodynamic parameters such as BP & HR ( baseline, at 5min, 10mins, thereafter, every 10 mins until OT is done & every 15min till 1 hour of the post-operative period). 2.Incidences of train of four normalized ratio of less than 0.9 during the 1st hour of the post-operative period. | — |
Countries
India
Contacts
Public ContactTAKHELMAYUM HEMJIT SINGH
Regional Institute of Medical Sciences
Outcome results
None listed