Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Accelerated iTBS: Accelerated iTBS will be performed using NEURO-MS.NET - magnetic stimulator software (version 3.2.10.1). The left DLPFC region of the brain will be targeted using neur
Sponsors
Sir Sunderlal Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of schizophrenia using diagnostic criteria of international classification of disease- 11th edition (ICD-11) 2.Male or female of age between 18 years to 60 years 3.Schizophrenia patients who haven’t received rTMS or ECT in the past 6 months 4.The Positive and negative syndrome scale for schizophrenia- negative symptoms score of more than 15 5.Scale for assessment of negative symptoms score more than 20 6.Willingness to give informed consent
Exclusion criteria
Exclusion criteria: 1.Presence of comorbid neurological, medical or other psychiatric disorder that are interfering with the study or patient being unmanageable due to acute illness or severity of the existing disorder 2.Patients with comorbid substance dependence, except nicotine and caffeine 3.Having any metallic implants/parts in body 4.Patients having a history of head trauma with loss of consciousness 5.Patients with a history of seizure/convulsion or having epilepsy or family history of same. 6.Patients with raised intracranial tension 7.Patients with a history of neurosurgery of any type ( brain or spinal cord)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To assess the efficacy of accelerated intermittent theta burst stimulation in negative symptoms of patients with schizophrenia 2.To compare the efficacy of accelerated intermittent theta burst stimulation in negative symptoms of schizophrenia patients with that of the control groupTimepoint: Baseline and 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the efficacy of accelerated intermittent theta burst stimulation in positive symptoms of patients with schizophrenia To compare the efficacy of accelerated intermittent theta burst stimulation in positive symptoms of schizophrenia patients with that of the control groupTimepoint: Baseline and 2 weeks;To assess the efficacy of accelerated intermittent theta burst stimulation in cognitive functions of patients with schizophrenia To compare the efficacy of accelerated intermittent theta burst stimulation in cognitive functions of schizophrenia patients with that of the control groupTimepoint: Baseline and 2 weeks;To assess the safety and tolerance of accelerated iTBS in patients with schizophreniaTimepoint: Baseline, 1 week and 2 weeks | — |
Countries
India
Contacts
Public ContactDr Vaishnavi Raj
Institute of medical sciences, BHU
Outcome results
None listed