Health Condition 1: I508- Other heart failure
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Sponsors
Dr Rachana G
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria Age eighteen years or older Diagnosis of Heart Failure established by Framingham criteria At least two major criteria, or One major and two minor criteria Diagnosis of Heart Failure with Preserved Ejection Fraction Presence of at least one symptom or sign of heart failure Left Ventricular Ejection Fraction equal to or greater than fifty percent as assessed by echocardiography Absence of alternative causes of heart failure symptoms including Severe aortic stenosis Significant valvular heart disease High likelihood of HFpEF as indicated by H2FPEF score equal to or greater than six with points assigned for Body mass index equal to or greater than thirty 2 points Hypertension or use of two or more antihypertensive medications 1 point Paroxysmal or persistent atrial fibrillation 3 points Pulmonary artery systolic pressure greater than thirty-five millimeters of mercury 1 point Age greater than sixty years 1 point E over e prime ratio greater than nine 1 point Elevated cardiac biomarkers consistent with heart failure NT-proBNP greater than four hundred fifty picograms per milliliter Availability of hemoglobin data for stratification Anemic Hemoglobin less than thirteen grams per deciliter for males Hemoglobin less than twelve grams per deciliter for females Non-anemic Hemoglobin within or above respective thresholds Echocardiographic measurements including TAPSE and PASP available informed consent
Exclusion criteria
Exclusion criteria: Exclusion criteria History of left ventricular ejection fraction less than fourty percentage reduction Congenital heart disease History of valvular heart disease Heart failure with improved ejection fraction Acute fluid overload Decompensated HF fluid resuscitation dialysis related volume shifts High output failure Constrictive pericarditis Previous heart transplantation Acute hemorrhagic anemia Idiopathic or hereditary Pulmonary artery hypertension Acute massive pulmonary embolism Chronic thromboembolic pulmonary hypertension Advanced COPD ILD OSA Hematological tumors Severe infection CKD with Egfr less than 30 Lack of relevant laboratory indicators Lack of data TAPSE PASP
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the association between anemia and right ventricular dysfunction in patients with heart failure with preserved ejection fraction assessed using the TAPSE by PASP ratio Timepoint: 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the correlation between severity of anemia and echocardiographic parameters of RV function including TAPSE PASP and tricuspid regurgitation grade To compare clinical and laboratory characteristics NYHA class NT-proBNP renal function between anemic and non-anemic HFpEF patients To identify independent predictors of RV dysfunction in HFpEF patients through multivariate regression analysis focusing on variables such as anemia severity atrial fibrillation iron deficiency and renal impairmentTimepoint: 18 months | — |
Countries
India
Contacts
Public ContactDr Rama Bhat
Kasturba Medical College Manipal
Outcome results
None listed