A study to compare how well dexmedetomidine reduces changes in blood pressure and heart rate when given in two different routes intravenously and intramuscularly during administration of general anaesthesia with endotracheal tube

a prospective study to compare the efficacy of intravenous versus intramuscular dexmedetomidine in attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096509

Enrollment

Registered

2025-10-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intramuscularly dexmedetomidine 1.5mcg/kg: Inj. Dexmedetomidine 1.5mcg/kg intramuscular 60 minutes prior to induction of general anaesthesia Control Intervention1: Intravenously dexmede

Eligibility

Inclusion criteria

Inclusion criteria: Patients willing to sign informed consent. Male or female patients between 18 to 60 years of age. Patients belonging to American Society of Anesthesiologists (ASA) physical status I and II. Patients posted for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients unwilling to participate in the study. Patients with Body Mass Index â‰¥ 30 kg/m2. Patients with history of muscular disorder , myositis , or any local infection Patients with cardiovascular diseases, arrhythmias, heart blocks, or taking beta blockers. Patients with cerebrovascular, hepatic and renal diseases. Psychiatric patients. Patients with history of allergy to an alpha 2 adrenergic agonist Pregnancy & lactating women.

Design outcomes

Primary

Measure	Time frame
To check efficacy of dexmedetomidine for blunting hemodynamic response during laryngoscopy and intubation in two different routes via intramuscular route and intravenous routeTimepoint: To check efficacy of dexmedetomidine for blunting hemodynamic response during laryngoscopy and intubation in two different routes via intramuscular route and intravenous route at baseline, after detest drug administration, after induction, at laryngoscopy and intubation, 1min, 3 mins, 5mins, 7mins after intubation	—

Measure

Time frame

To check efficacy of dexmedetomidine for blunting hemodynamic response during laryngoscopy and intubation in two different routes via intramuscular route and intravenous routeTimepoint: To check efficacy of dexmedetomidine for blunting hemodynamic response during laryngoscopy and intubation in two different routes via intramuscular route and intravenous route at baseline, after detest drug administration, after induction, at laryngoscopy and intubation, 1min, 3 mins, 5mins, 7mins after intubation

—

Secondary

Measure	Time frame
To study sedation score or any other side effectsTimepoint: post-operatively sedation status will be assessed every 30 minutes by RAMSAY sedation score till a score of less than or equal to 3 will be achieved.	—

Countries

India

Contacts

Public ContactDr Sara Mary Thomas

Smt. Bhikiben Kanjibhai Shah Medical Institute and Research Centre

sara.cinosh@gmail.com9646500158

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026