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Detection of cancer inducing gene p53 in blood DNA of patients with proven skin cancer or pre cancerous lesions to determine if it can serve as early indicators of malignant transformation and to monitor disease progression of the same.

Detection of p53 Gene Mutation from Blood DNA in Cutaneous Malignant and Premalignant Conditions – A Case-Control Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/10/096500
Enrollment
62
Registered
2025-10-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C43- Malignant melanoma of skin

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

DR PRITIKA RAJESH MARAVOOR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with dermoscopically or histologically confirmed BCC, cutaneous SCC, or melanoma and premalignant lesions like actinic keratosis, Bowens disease and Bowenoid papulosis. Healthy volunteers matched for age and gender as controls.

Exclusion criteria

Exclusion criteria: Individuals with hematological or systemic malignancies. Immunocompromised patients for e.g., HIV, chemotherapy

Design outcomes

Primary

MeasureTime frame
To Detect presecnce of p53 mutation in peripherally Blood derived DNA from patients with Cutaneous Malignant and Premalignant ConditionsTimepoint: Detection of p53 Gene Mutation from Blood DNA in Cutaneous Malignant and Premalignant Conditions—

Secondary

MeasureTime frame
to compare the prevalance of p53 mutations between malignant, premalignant and healthy controlsTimepoint: Detection of p53 Gene Mutation from Blood DNA in Cutaneous Malignant and Premalignant Conditions at the time of diagnosis—

Countries

India

Contacts

Public ContactDR PRITIKA RAJESH MARAVOOR

SHRI B. M PATIL MEDICAL COLLEGE AND RESEARCH HOSPITAL

ajitjanagond@gmail.com8884009497

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026