Comparing the efficacy of intranasal, nebulized, and intravenous routes of dexmedetomidine for blunting hemodynamic response to laryngoscopy and tracheal intubation in elective intracranial surgeries - A prospective, randomized, single blind clinical study.

Comparison of efficacy of intranasal nebulized and intravenous routes of dexmedetomidine for blunting hemodynamic response to laryngoscopy and tracheal intubation in elective intracranial surgeries. A prospective randomized single-blind clinical study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096451

Enrollment

132

Registered

2025-10-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D496- Neoplasm of unspecified behavior of brain

Interventions

Intervention1: Intranasal Dexmedetomidine: Intranasal dexmedetomidine at dose of 1mcg/kg using nasal atomizer given 30 mins before induction Intervention2: Nebulized dexmedetomidine: Nebulized dexmede

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients of either gender 2)Age 18 to 65 years 3)ASA class I and II 4)Patients with GCS 12 to 15

Exclusion criteria

Exclusion criteria: 1)Patient refusal 2)Patients with anticipated difficult airway 3)Patients with hypertension or respiratory disorders or hepatic dysfunction or renal dysfunction 4)Patients undergoing emergency surgery 5)Pregnant patients

Design outcomes

Primary

Measure	Time frame
To compare the hemodynamic response between the intranasal, nebulized, and intravenous dexmedetomidine as premedication for blunting laryngoscopy and tracheal intubation response.Timepoint: Till 15 minutes after intubation	—

Secondary

Measure	Time frame
To compare the sedation score To compare the adverse effects of dexmedetomidine administration via three routesTimepoint: Till 15 minutes after intubation	—

Countries

India

Contacts

Public ContactDr Monica Malhotra

AIMS, RAIPUR

monicakhetrapal@yahoo.com8518881714

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026