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To study the Effect Of Ondansetron On The Dose Of Ephedrine Needed To Prevent Low Blood Pressure In Planned Cesarean Sections Under Spinal Anaesthesia

Effect Of Ondansetron On The Dose Of Ephedrine In Elective Cesarean Section Under Spinal Anaesthesia: A Randomised Controlled Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096428
Enrollment
110
Registered
2025-10-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O746- Other complications of spinal andepidural anesthesia during labor and delivery

Interventions

Intervention1: NIL: NIL Control Intervention1: Intravenous Ondansetron: Administration of intravenous Ondansetron 5 minutes prior to administration of spinal anaesthesia. Control Intervention2: Intrav

Sponsors

MS Ramaiah Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -Pregnant women between ages 20-40 years -American Society of Anaesthesiologists Physical Status II -Planned elective Lower Segment Cesarean Section under spinal anaesthesia -Singleton pregnancies

Exclusion criteria

Exclusion criteria: -Contraindications to spinal anaesthesia (e.g., blood clotting disorders, severe hypotension) -Allergies to ondansetron or local anaesthetics -History of pregnancy-induced hypertension, per-eclampsia, eclampsia. -Pre-existing heart conditions -Use of serotonin-modulating drugs -Failed Spinal Anaesthesia and it’s conversion to General Anaesthesia

Design outcomes

Primary

MeasureTime frame
Total dose of Ephedrine required to maintain blood pressure in the two groupsTimepoint: Intraopeartive duration of surgery—

Secondary

MeasureTime frame
Umbilical artery pHTimepoint: Cord blood gas analysis done once the baby is delivered;Incidence of Bradycardia and HypotensionTimepoint: Intraoperative duration of surgery;Ondansetron’s impact on nausea, vomitingTimepoint: Intraoperatively and in Post-Anaesthesia Care Unit.—

Countries

India

Contacts

Public ContactDr Leena H Parate

MS Ramaiah Medical College and Hospital

dr_leenag@yahoo.co.in9480525925

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026