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Comparison of Dexmedetomidine and Propofol sedation for Evaluating the upper airway in patients with Obstructive Sleep Apnea

A Comparative Study Using Dexmedetomidine Continuous Infusion versus TCI-Propofol for Patients Undergoing DISE – A Single-Centre Prospective Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096405
Enrollment
58
Registered
2025-10-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dexmedetomidine Infusion: Loading dose of 1mcg/kg over 10 minutes followed by maintenance infusion at 0.2-0.7mcg/kg/hr during DISE Study Intervention2: Target-Controlled infusion (TCI)

Sponsors

AIG Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with OSA requiring evaluation of Upper Airway collapse during sleep

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Age 65yrs 3. ASA status > III 4. Severe Obesity BMI > 40kg/m2 5. Known Allergy to dexmedetomidine or propofol

Design outcomes

Primary

MeasureTime frame
Comparision of sedation quality and hemodynamic stability between Dexmedetomidine infusion and TCI Propofol during Drug-Induced Sleep Endoscopy, assessed using BIS ScoreTimepoint: 1.Baseline (Pre-sedation) 2.After achieving the target Sedation 3.Every 5 minutes during the procedure 4.Immediate post-procedure—

Secondary

MeasureTime frame
Incidence of acute upper airway collapse requiring airway adjuncts & oxygen supportTimepoint: Observed till 30 minutes post-injection—

Countries

India

Contacts

Public ContactHabeeb Rizwan

AIG Hospitals

r.habeeb@outlook.com9052126261

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026