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Comparison of Herbal (Curcumin-Piperine-Lycopene) and Conventional (Calcium Hydroxide) Intracanal Medicaments for Pain Relief in Patients with Symptomatic Irreversible Pulpitis

Evaluation of safety and efficacy of Curcumin- Piperine- Lycopene combination versus Calcium Hydroxide as Intracanal Medicaments on pain relief in symptomatic Irreversible Pulpitis. - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096399
Enrollment
60
Registered
2025-10-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Curcumin- Piperine- Lycopene: Participants of the study fulfilling the inclusion criteria will undergo the interventions. Patient will be given local anesthesia. Rubber dam will be app

Sponsors

Dr Krishna prasad Biswas
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: i. Patient visiting Out Patient Department at AIIMS Guwahati ii. Patient aged 18 -65 in good health and absence of disease iii. Single rooted maxillary and mandibular teeth with irreversible pulpitis iv.Informed Consent

Exclusion criteria

Exclusion criteria: i. Failure to give consent ii. Medically comprised iii. Pregnant patient iv. More than 1 root canal in tooth v. Teeth with Periapical radiolucency vi Had taken medication within 12 hrs of study

Design outcomes

Primary

MeasureTime frame
The curcumin-based group is expected to show a statistically significant reduction in inter-appointment pain and tenderness better or comparable outcome to traditional agents like calcium hydroxide . The study anticipates fewer analgesic requirements With better healing and recovery, prognosis of root canal treated teeth will be improved. Timepoint: 1st day 3rd day 5th day 7th day

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Ajay Chhabra

AIIMS Kalyani

ajay.dental@aiimskalyani.edu.in9417200001

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026