Studying how Vitamin C affects post-surgical pain in patients having Head and Neck Surgery.

The Effect of Intra-operative Intravenous Vitamin C Supplementation on post-operative pain in patients undergoing Reconstructive Head and Neck Flap Surgeries: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096373

Enrollment

Registered

2025-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Vitamin C: Dose of Vitamin C 3g (30ml) Frequency Once Route of administration Intravenous Total duration of this intervention 20 minutes All the patients in this arm will be given Inj

Eligibility

Inclusion criteria

Inclusion criteria: Patients who give consent for head and neck flap (local and pedicle) surgery and intravenous Vitamin C ASA 1 and ASA 2 G6PD normal patients Hemodynamically stable patients undergoing head and neck reconstructive flap surgeries

Exclusion criteria

Exclusion criteria: Age below 17 years and above 65 years Patient who refuse to be a part of the study ASA 3 and above patients (cardiac and renal failure patients) Pregnant women G6PD deficient patients Patient with history of allergy to Vitamin C History of chronic opioid use

Design outcomes

Primary

Measure	Time frame
To assess the effect of Vitamin C supplementation in postoperative pain (VAS score at 6 hours) in patients undergoing reconstructive Head and Neck flap surgeries (local and pedicled flap).Timepoint: 6 hours postoperatively	—

Secondary

Measure	Time frame
VAS score at 0,12 and 24 hours postoperativelyTimepoint: 0,12 and 24 hours;Time to rescue analgesic requestTimepoint: Till 24 hours postoperatively;Measure the amount of postoperative analgesic requirementTimepoint: Till 24 hours postoperatively;To evaluate the length of hospital stayTimepoint: Date of discharge	—

Countries

India

Contacts

Public ContactDr Serina Ruth Salins

Christian Medical College Vellore

serina.ruth@cmcvellore.ac.in9442307738

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026