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Checking for early kidney problems in children with cancer taking treatment

Correlation of urinary KIM-1 and NAG with Serum Creatinine for early detection of Acute kidney injury in Pediatric cancer patients receiving chemotherapy-A one year cross sectional study in Belagavi - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/10/096353
Enrollment
60
Registered
2025-10-22
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N179- Acute kidney failure, unspecified

Interventions

Intervention1: Nil: Nil Control Intervention1: URINE AND BLOOD INVESTIGATIONS: COMPARING URINE KIM-1 AND NAG WITH SERUM CREATININE

Sponsors

Dr Gouri M Patil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 1- 18 years diagnosed with malignant diseases and receiving chemotherapy agents with renal route of excretion causing Acute Kidney Injury like (ex: methotrexate, cisplatin, carboplatin etc.) and Chemotherapy agents causing with non-renal route of excretion causing Acute Kidney Injury (Vincristine, Cytarabine, Etoposide etc. ) at KLE Hospital, Belagavi.

Exclusion criteria

Exclusion criteria: Pre-existing CKD Structural renal anomalies. Post – Nephrectomy Renal tumors. Who have received nephrotoxic antibiotics greater than 10 days. Administration of contrast medium in the previous 14 days. Incomplete data or refusal of consent.

Design outcomes

Primary

MeasureTime frame
To correlate the efficacy of selected urinary biomarker’s i.e. urinary KIM-1 and urinary NAG with serum creatinine in the early detection of Acute Kidney Injury (AKI) among pediatric cancer patients receiving chemotherapy agents.Timepoint: 0 hours and 24 hours—

Secondary

MeasureTime frame
1 To determine the risk factors of Acute Kidney Injury in pediatric oncology patients receiving chemotherapy 2 To evaluate the diagnostic timeline of biomarkers like KIM1 And NAG at baseline 0 hour before chemotherapy And 24 hours post chemotherapy with elevation of serum creatinine 3 To assess the stage of Acute Kidney Injury as per KIDGO criteria Timepoint: NIL—

Countries

India

Contacts

Public ContactDr Gouri M Patil

Jawaharlal Nehru Medical College

drmahanteshvpatil@gmail.com9483561674

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026