Comparing the effects of Lidocaine vs Esmolol in reducing the variations in Blood pressure, Pulse Rate and Oxygen Saturation during laryngoscopy and endotracheal intubation in patients who are undergoing laparoscopic surgeries

Comparison of efficacy between Esmolol IV vs Lidocaine IV in attenuation of haemodynamic stress response during laryngoscopy and endotacheal intubation in laparoscopic surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096295

Enrollment

Registered

2025-10-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K352- Acute appendicitis with generalized peritonitis Health Condition 2: K353- Acute appendicitis with localizedperitonitis Health Condition 3: K358- Other and unspecified acute appendicitis Health Condition 4: K36- Other appendicitis Health Condition 5: K37- Unspecified appendicitis Health Condition 6: K389- Disease of appendix, unspecified Health Condition 7: K400- Bilateral inguinal hernia, with obstruction, without gangrene Health Condition 8: K402- Bilateral inguinal he

Interventions

Intervention1: Inj Lidocainie 2 mg/kg: Inj Lidocaine 2 mg/kg IV is given 3 minutes prior to larngoscopy and endotracheal intubation Control Intervention1: Inj Esmolol 2 mg/kg: Inj Esmolol 2 mg/kg IV g

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA 1.Patients willing to sign informed consent 2.Male or Female patients between 18 to 60 years of age 3.Patients belonging to American Society of Anaesthesiologists(ASA) physical status I & II 4.Patients posted for elective laparoscopic surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Patients unwilling to participate in study. 2.Patients with Body Mass Index more than 29 Kg per metre square 3.Patients with cerebrovascular diseases, hepatic and/or renal diseases 4.Psychiatric patients 5.Pregnancy and lactating women 6.Patients belonging to American Society of Anaesthesiologists (ASA) III and above.

Design outcomes

Primary

Measure	Time frame
Changes in Systolic and Diastolic Blood Pressures, Pulse Rate, Oxygen SaturationTimepoint: 1) Three minutes prior to laryngoscopy and endotracheal intubation - recorded as baseline 2. During laryngoscopy and endotracheal intubation 3. One minute after laryngoscopy and endotracheal intubation 4. Three minutes after laryngoscopy and endotracheal intubation 5. Five minutes after laryngoscopy and endotracheal intubation 6. Seven minutes laryngoscopy and endotracheal intubation 7. Nine minutes after laryngoscopy and endotracheal intubation	—

Measure

Time frame

Changes in Systolic and Diastolic Blood Pressures, Pulse Rate, Oxygen SaturationTimepoint: 1) Three minutes prior to laryngoscopy and endotracheal intubation - recorded as baseline 2. During laryngoscopy and endotracheal intubation 3. One minute after laryngoscopy and endotracheal intubation 4. Three minutes after laryngoscopy and endotracheal intubation 5. Five minutes after laryngoscopy and endotracheal intubation 6. Seven minutes laryngoscopy and endotracheal intubation 7. Nine minutes after laryngoscopy and endotracheal intubation

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Kalpesh Patil

Smt. Bhikiben Kanjibhai shah Medical Institute & Research Centre,

drkalpeshpatil86@gmail.com7058308703

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026