Study to Compare Three Medicines i.e., Furosemide and Salty Water (3 percent and 0.9 percent sodium chloride) given via steam inhalation before surgery to prevent Sore Throat in patients undergoing Keyhole (laparoscopic) Surgery for Uterus Removal under General Anaesthesia

Comparison of Pre-Operative Nebulisation with Furosemide, 3 Percent Sodium Chloride and 0.9 Percent Sodium Chloride in Prevention of Post-Operative Sore Throat in Patients undergoing Total Laparoscopic Hysterectomy under General Anaesthesia: A Double-Blinded Randomised Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096277

Enrollment

144

Registered

2025-10-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N711- Chronic inflammatory disease of uterus

Interventions

Intervention1: Pre operative Nebulisation with Furosemide 30 mg (3ml) and 1ml of 0.9 percent Normal Saline to make a solution of 4ml: Preoperative nebulisation will be administered 15 minutes before i

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than 18 yrs 2. ASA I and ASA II class 3. MP grade 1 and 2 4. Neck Circumference less than 40cm 5. posted for elective Total Laparoscopic Hysterectomy surgery under General Anaesthesia 6. No History of URTI in 2 weeks prior to surgery and any respiratory disorders

Exclusion criteria

Exclusion criteria: 1. Patient who are not willing to participate in the study 2. difficult airway 3. History of COPD or Respiratory disorders. 4. History of URTI within 2 weeks prior to surgery 5. more than 1 attempt or more than 30 seconds at intubation. 6. Surgery time more than 3hrs 7. known allergy to either drugs 8. smokers 9. obese patients

Design outcomes

Primary

Measure	Time frame
To compare the incidence and severity of Post Operative Sore Throat in Patients undergoing Total Laparoscopic Hysterectomy under General Anaesthesia after giving Pre operative Nebulisation with Furosemide and 3% Normal Saline.Timepoint: standardised four point scale (0-3) at 2 hours, 4 hours and 6 hours post operatively.	—

Secondary

Measure	Time frame
To compare the acceptability of the drugsTimepoint: standardised three point scale at 20 minutes from administration of nebulisation;To compare the incidence & severity of Post Operative Nausea Vomiting with the two drugsTimepoint: standardised three point scale (0-2) at 2, 4, 6 hours post operatively;To compare the Cost Effectiveness of the two drugsTimepoint: Upon Statistical Analysis	—

Countries

India

Contacts

Public ContactDr Rajib Lochan Samal

Institute of Medical Sciences and SUM Hospital

samal.rajib2013@gmail.com8763763798

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026