To compare the difference in the amount of blood loss during the first 24 hours after cesarean section on giving intrauterine misoprostol in one group and per rectal misoprostol in another group

Intrauterine Misoprostol Versus per Rectal Misoprostol During Cesarean Section to Prevent Primary Postpartum Hemorrhage-- A Comparative analysis - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096250

Enrollment

200

Registered

2025-10-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O720- Third-stage hemorrhage

Interventions

Intervention1: Use of intrauterine misoprostol in preventing primary post partum hemorrhage during cesarean section: 400 mcg misoprostol will be introduced intrauterine ( 200mcg in each cornu) in firs

Eligibility

Inclusion criteria

Inclusion criteria: Women bearing full term singleton healthy living fetus with gestational age more than 37 weeks either confirmed from first date of last menstrual period or first trimester ultrasound scan

Exclusion criteria

Exclusion criteria: Women with pre operative hemoglobin less than 9gm/dl , concomittant medical disorders, more than two previous cesarean section, allergic to prostaglandin, with higher risk of post partum hemorrhage ( abnormal placentation, twin pregnancy, previous history of uterine atony or PPH, polyhydramnios,uterine fibroids ) , women in whom cesarean section lasts for more than 90 minutes

Design outcomes

Primary

Measure	Time frame
To study efficacy and safety of intrauterine misoprostol in preventing primary post partum hemorrhage during cesarean section as compared to per rectal misoprostol during cesarean sectionTimepoint: 24hours	—

Secondary

Measure	Time frame
1) to compare use of additional uterotonics following intrauterine misoprostol administration 2) to compare blood transfusion following intrauterine misoprostol administration 3) to compare hospital stay following intrauterine misoprostol administration 4) to study side effects of misoprostolTimepoint: 24hours	—

Countries

India

Contacts

Public ContactSnehamay Chaudhuri

Midnapore medical college and hospital

snehamay_chaudhuri_dr@yahoo.com9830538366

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026