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Comparing 2 drugs in reducing coughing response during endotracheal extubation: A controlled study

Comparison between clonidine and dexmedetomidine in suppressing cough response during tracheal extubation : A controlled study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096174
Enrollment
96
Registered
2025-10-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: Clonidine: Patients receive 0.75mcg/kg of Clonidine diluted upto 100ml NS, given over 10 minutes before extubation Intervention2: Dexmedetomidine: Patients receive 0.5mcg/kg of Dexmedet

Sponsors

M S Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating mothers 2. Severe cardiovascular, renal or hepatic disorders 3. People who are allergic to the study drugs 4. Patients with anticipated difficult airway 5. Patients who are already on study drugs 6. Patients with any respiratory diseases

Design outcomes

Primary

MeasureTime frame
Cough scoreTimepoint: During extubation—

Secondary

MeasureTime frame
Hemodynamic responsesTimepoint: During extubation;Sedation scoreTimepoint: During extubation—

Countries

India

Contacts

Public ContactDr Leena H Parate

M S Ramaiah Medical College and Hospital

dr_leenag@yahoo.co.in9480525925

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026