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To determine whether using the right chest artery is as safe and effective as using the left chest artery for restoring blood flow to the heart’s major front artery (the left anterior descending artery) in coronary bypass surgery.

A prospective, single center, randomized trial comparing the use of the right internal thoracic artery (RITA) versus the left internal thoracic artery (LITA) for grafting the left anterior descending artery (LAD) in multi-arterial coronary bypass grafting (CABG) - PATROL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096140
Enrollment
306
Registered
2025-10-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: LIMA-LAD: Arm A (Control group): Standard CABG with in-situ LIMA grafted to the LAD (LIMA-LAD). The RIMA is harvested and used as a second arterial graft to another target (e.g. to the

Sponsors

STAR hospitals
Lead Sponsor
Dandu Satya Bhaskara Raju
Collaborator
Gopichand Mannam
Collaborator
Lokeswara Rao Sajja
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Aged between 18 to 70 years 2. Multi-vessel CAD involving the LAD artery and circumflex artery or LMCA 3. Requiring isolated nonemergent primary CABG 4. For diabetic patients, HbA1c less than or equal to 10 percent 5. Left ventricular ejection fraction greater than or equals to 35 percent 6. Serum creatinine less than or equal to 1.5mg/dL 7. Able to provide written informed consent

Exclusion criteria

Exclusion criteria: 1. Aged less than 18 years and more than 70 years. 2. CAD involving non-LAD or non-circumflex arteries 3. HbA1c more than 10 percent 4. Left ventricular ejection fraction less than 35 percent 5. Patients undergoing combined procedures 6. Emergent or urgent CABG 7. Patients undergoing redo CABG 8. Previous Cardiac Surgery 9. Preoperative severe end-organ dysfunction (on maintanance hemodylis, liver failure, respiratory failure), cancer or any comorbidity that reduce life expectancy to less than 5 years 10. Unsuitable internal thoracic arteries 11. Symptomatic carotid artery stenosis (more than 70 percent) 12. Not able to provide written informed consent

Design outcomes

Primary

MeasureTime frame
To evaluate graft patency at 3 months for RIMA to LAD OR LIMA to LAD following coronary artery bypass grafting (CABG)Timepoint: 3 months—

Secondary

MeasureTime frame
To compare the incidence of major adverse cardiac and cerebrovascular events (MACCE) at 1 year between the RIMA-LAD and LIMA-LAD groups, including a composite of all-cause mortality, non-fatal myocardial infarction, stroke, and repeat revascularizationTimepoint: At 1 year—

Countries

India

Contacts

Public ContactLokeswara Rao Sajja

STAR Hospitals

sajjalr@starhospitals.in9849028317

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026