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Using ultrasound to see how well a patient can breathe on their own before removing breathing machine (ventilator) support in ICU patients

Accuracy of cardiorespiratory ultrasound assessment for predicting weaning failure during spontaneous breathing trial: An observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/10/096138
Enrollment
140
Registered
2025-10-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R918- Other nonspecific abnormal findingof lung field

Interventions

Intervention1: Nil: Nil Intervention2: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Lady Hardinge Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age group more than equal to 18 years age of either gender who are on invasive mechanical ventilation for more than 48 hours and are eligible for spontaneous breathing trial (SBT). 2. Patients meeting the following criteria for SBT: a. Resolution of the acute phase of the underlying condition that led to mechanical ventilation b. Adequate oxygenation (PaO2/FiO2 more than equal to 200, PEEP less than equal to 8 cm H2O, FiO2 less than equal to 0.4) c. Hemodynamic stability (no vasopressors or low-dose vasopressors) d. Adequate mental status (able to follow commands) e. Temperature less than 38.5°C f. Adequate cough reflex

Exclusion criteria

Exclusion criteria: 1. Any pregnant patient 2. Patient having rib fractures or flail chest or severe chest wall deformities 3. Any patient with cervical spine injury 4. Patients having pneumothorax (false lowering of LUS scores-suggesting better aeration than exists) 5. Poor ultrasound image views 6. Documented paradoxical movement of diaphragm or hemi-diaphragm on ultrasound

Design outcomes

Primary

MeasureTime frame
To predict accuracy (of cardiorespiratory ultrasound assessment for weaning failure during spontaneous breathing trial.Timepoint: T1- During SBT on PS 8 cm H20, PEEP less than equal to 5 cm H20- Week 0 (Day of SBT initiation) T2-During SBT on T-pieceWeek 0 (same session, following T1) T3-After SBT- Within 1 hour post-SBT (Week 0)—

Secondary

MeasureTime frame
1. Predictive accuracy of individual ultrasound modalities (cardiac, lung, & diaphragm) for weaning failure. 2. Predictive accuracy of conventional weaning parameters (RSBI, P0.1) for weaning failure. Timepoint: T1- During SBT on PS 8 cm H20, PEEP less than equal to 5 cm H20- Week 0 (Day of SBT initiation) T2-During SBT on T-piece Week 0 (same session, following T1) T3-After SBT- Within 1 hour post-SBT (Week 0)—

Countries

India

Contacts

Public ContactPriyanka Dhar

Lady Hardinge Medical College and associated hospitals

drkumaranil@yahoo.com8084660100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026