Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: 7% HYPERTONIC SALINE: Intervention:
• Name of intervention: 7% Hypertonic Saline
• Type: Active intervention
• Route of administration: Nebulization
• Dosage/Form: 7% saline solutio
serves as comparator to assess efficacy and safety differences.
Sponsors
Dr Ruchi Dua
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged eighteen years and above. Patients presenting with clinical or radiological features suggestive of pulmonary tuberculosis as per WHO criteria, such as cough for more than two weeks, fever, weight loss, night sweats, and chest radiograph showing infiltrates, cavitation, fibrotic changes, miliary pattern, or mediastinal lymphadenopathy. Patients unable to produce sputum spontaneously. Patients willing to participate and providing written informed consent to undergo sputum induction.
Exclusion criteria
Exclusion criteria: Oxygen saturation less than ninety-two percent on room air. Known or uncontrolled asthma or chronic obstructive pulmonary disease. Active hemoptysis at the time of enrolment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adequacy and Volume of Sputum Sample based on NTEP criteria more than 2 ml with adequate cellular content as per Bartlett scoreTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| TB Detection Rate by GeneXpert or NAAT & AFB smear positivity Timepoint: At baseline;Incidence of Side Effects like dyspnea-VAS, excessive coughing-1-10 scale, throat irritation, desaturation more than 3 percent upto 30 minutes post nebulisation Timepoint: within 30 min post procedure;Patient Comfort Assessment using Visual Analogue Scale using VAS on 1–10 scale Timepoint: baseline during procedure | — |
Countries
India
Contacts
Public ContactRUCHI DUA
AIIMS RISHIKESH
Outcome results
None listed