A study comparing two ways of giving a medicine called glycopyrrolate by inhaling or by injection to help make awake intubation easier in adults

Comparative efficacy of inhaled glycopyrrolate and intravenous glycopyrrolate for optimizing awake fibreoptic intubation conditions in adult patients a double blind randomized controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096109

Enrollment

Registered

2025-10-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: intravenous: administering 0.2mg glycopyrrolate once in a patient as per randomisation via intravenous route 30min prior intubation Control Intervention1: inhalation: administering 50mc

Eligibility

Inclusion criteria

Inclusion criteria: Patients with anticipated difficult airway requiring AFOI and ASA physical status I to III

Exclusion criteria

Exclusion criteria: Allergy to glycopyrrolate Severe cardiac arrhythmias or uncontrolled tachycardia or bradyarrhythmia History of chronic respiratory disease affecting on treatment with anticholinergics Patients with altered mentation unable to comprehend the procedure cooperate or give consent Myasthenia gravis Patients using Contact lenses Patients with prostatic diseases Glaucoma

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of inhaled and intravenous glycopyrrolate in improving AFOI conditions, assessed using Secretion Score Glottic visualizationTimepoint: outcome will be accessed immediately while 01min to 10min of intubation time Intraoperative Haemodynamic parameters will be accessed baseline,15min,30min,45min,60min interval post op side effects will be monitored 15min after extubation	—

Secondary

Measure	Time frame
Time taken to reach carina To evaluate the hemodynamic effects heart rate & blood pressure changes of both administration routes To assess patient comfort & adverse effects eg dry mouth tachycardia To determine the need for additional interventions such as suctioning or repeat intubation attemptsTimepoint: time taken to carina will be noted Intraoperative Haemodynamic parameters will be accessed baseline,15min,30min,45min,60min interval post op side effects will be monitored 15min after extubation	—

Measure

Time frame

Time taken to reach carina To evaluate the hemodynamic effects heart rate & blood pressure changes of both administration routes To assess patient comfort & adverse effects eg dry mouth tachycardia To determine the need for additional interventions such as suctioning or repeat intubation attemptsTimepoint: time taken to carina will be noted Intraoperative Haemodynamic parameters will be accessed baseline,15min,30min,45min,60min interval post op side effects will be monitored 15min after extubation

—

Countries

India

Contacts

Public ContactAkash Ray Mohapatra

Armed Forces Medical College

rainaajit@gmail.com8171505533

Outcome results