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Brain and nerve stimulation for depression in cancer patients receiving radiation.

Comparing the effect of Transcranial direct current stimulation versus Transauricular vagus nerve stimulation on depressive symptoms in cancer patients undergoing radiation therapy- A Randomised Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096105
Enrollment
22
Registered
2025-10-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C801- Malignant (primary) neoplasm, unspecified

Interventions

Intervention1: taVNS + Conventional physiotherapy: Training frequency- 5 sessions per week Training duration- 30 minutes Number of weeks- 2 weeks Exercises- 30 minutes per session Intervention2: tDCS

Sponsors

Gayatri Govindankutty Marar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Participant diagnosed with cancer who are in the age group of 40 to 80 years of both genders. 2.Participants willing to participate. 3. Participants with beck depression inventory more than 13.

Exclusion criteria

Exclusion criteria: 1.Participants having any metal implants. 2.Participants who are undergoing any forms of psychotherapy. 3.Participants having history of uncontrolled epilepsy. 4.Participants having pacemaker. 5.Participants with acute ear infections. 6.Participants with cardiovascular risk or unstable cardiac disease. 7.Participants with unstable medical conditions. 8.Participants with active skin disease at electrode sites

Design outcomes

Primary

MeasureTime frame
PHQ-9 scale is used to assess the depression and is assessed post interventionTimepoint: baseline and at 2 weeks

Secondary

MeasureTime frame
fatigue severity scale is used to assess fatigue level of the patientTimepoint: baseline & at 2 weeks;EORTC QOL-C30 scale is used to assess the quality of lifeTimepoint: baseline & at 2 weeks

Countries

India

Contacts

Public ContactDr Raghavendrasingh Dharwadkar

KLE Institute of Physiotherapy

gayatrimarar23@gmail.com07902341557

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026