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Fissure treatment using platelet rich plasma

Platelet-Rich Plasma (PRP) augmentation vs Lateral Internal Sphincterotomy(LIS) alone in the Management of Chronic Fissure-in-Ano: A Double-Blind Randomized Controlled Trial( PRISMA-F Trial) Platelet-Rich plasma vs Internal Sphincterotomy in the Management of Chronic Anal Fissure(PRISMA -F) - PRISMA - F Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096064
Enrollment
98
Registered
2025-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K928- Other specified diseases of the digestive system Health Condition 2: K928- Other specified diseases of the digestive system

Interventions

Intervention1: Platelet-Rich Plasma (PRP) augmentation: patients own blood is drawn, spun in a centrifuge to concentrate platelets, and then injected into the Fissure site after LIS Duration - One mon

Sponsors

All India Institute of Medical Sciences Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient more than 18 years planned for LIS

Exclusion criteria

Exclusion criteria: Patients with contraindication to LIS, refusal to participate in the study.

Design outcomes

Primary

MeasureTime frame
Time to Complete Healing: Defined as the number of days from surgery to the complete healing of the FissureTimepoint: Time to Complete Primary outcome - 4 weeks—

Secondary

MeasureTime frame
Pain during defecation – Measured by VAS score at 7,14,21,30 and 60 days Recurrence Rate: Assessed at one-year post-treatment through clinical examination Timepoint: Bleeding during defecation - Evaluiated at 7,14,21,30 and 60 days Recurrance - 1 year—

Countries

India

Contacts

Public ContactDr Pankaj Kumar

AIIMS Bhubaneswar odisha

drpkushwaha@gmail.com9438884253

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026