A comparison of the effectiveness of two anesthesia techniques—the nerve block and intraosseous injection—used during pulpotomy of lower molars with severe tooth nerve inflammation

Comparative evaluation of the anesthetic efficacy of inferior alveolar nerve block and intraosseous injection during pulpotomy in mandibular molars with symptomatic irreversible pulpitis: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/096049

Enrollment

Registered

2025-10-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K040- Pulpitis

Interventions

Intervention1: Intraosseous Injection: The intraosseous anesthesia will be administered using the QuickSleeper system integrated with dynamic navigation technology followed by full pulpotomy procedure

Eligibility

Inclusion criteria

Inclusion criteria: Healthy patient of either gender between 15-35 years of age group. Mandibular molar teeth with deep or extremely deep caries Teeth with symptomatic irreversible pulpitis Teeth without periapical rarefaction Teeth with positive response to cold and electric pulp test

Exclusion criteria

Exclusion criteria: Preoperative: Teeth with immature roots, crown originating fractures or non-restorable carious lesion Teeth with poor periodontal health, probing pocket depth less than 3mm Patients with history of mandibular 3rd molar extraction Hypertensive patients and patients with systemic conditions which could compromise the healing. Any medical contraindication to the use of anesthetics containing vasoconstrictors Intraoperative Bleeding cannot be controlled within 10 mins Clinical diagnosis changes to pulp necrosis

Design outcomes

Primary

Measure	Time frame
1) To assess the effectiveness of using intraosseous injection as the main anesthetic method for performing pulpotomy in mandibular molars affected by symptomatic irreversible pulpitis 2) To assess the effectiveness of using inferior alveolar nerve block as the main anesthetic method for performing pulpotomy in mandibular molars affected by symptomatic irreversible pulpitis 3) To compare the efficacy of inferior alveolar nerve block and Intraosseous injection as primary anesthetic method for performing pulpotomy in carious exposed mandibular symptomatic irreversible pulpitisTimepoint: The patient will be contacted via telephone and the intensity of pain will be recorded using NRS at 24 hrs, 48hrs and 72hrs	—

Measure

Time frame

1) To assess the effectiveness of using intraosseous injection as the main anesthetic method for performing pulpotomy in mandibular molars affected by symptomatic irreversible pulpitis 2) To assess the effectiveness of using inferior alveolar nerve block as the main anesthetic method for performing pulpotomy in mandibular molars affected by symptomatic irreversible pulpitis 3) To compare the efficacy of inferior alveolar nerve block and Intraosseous injection as primary anesthetic method for performing pulpotomy in carious exposed mandibular symptomatic irreversible pulpitisTimepoint: The patient will be contacted via telephone and the intensity of pain will be recorded using NRS at 24 hrs, 48hrs and 72hrs

—

Secondary

Measure	Time frame
To evaluate and compare the outcome of Pulpotomy performed under Intraosseous Injection and Inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitisTimepoint: One year follow up, Recall at 6 months	—

Countries

India

Contacts

Public ContactDr Vijay Kumar

Centre for Dental Education and Research ,All India Institute of Medical Sciences ,New Delhi -110029

kumarvijay29@gmail.com9540055001

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026