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A study comparing two hormonal trigger methods before egg collection to assess embryo quality in women with poor ovarian response undergoing IVF

Double vs Dual Trigger in POSEIDON 3–4: A Multicenter RCT on Embryo quality in Poor Responders - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/096009
Enrollment
150
Registered
2025-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Intervention Arm (Double Trigger): : Given once on day of trigger for oocyte maturation when at least 2-3 follicles are more than 17mm in size. GnRH agonist at 38–40h + HCG/rHCG at 35

Sponsors

OSHERM, Oasis Fertility
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Infertile women with low ovarian reserve as per POSEIDON criteria.

Exclusion criteria

Exclusion criteria: Severe systemic illness Contraindication to GnRH agonist or HCG Participation in another clinical trial

Design outcomes

Primary

MeasureTime frame
Oocyte retrieval rate Number of mature oocytes retrieved Fertilization rate Blastulation rate Number of top-quality embryosTimepoint: 1 year—

Secondary

MeasureTime frame
Oocyte retrieval rate Fertilization rate Blastulation rateTimepoint: 1 year—

Countries

India

Contacts

Public ContactDr Parinaaz Parhar

OSHERM

parinaaz.parhar@oasisindia.in9881474476

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026