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The role of antibiotic loaded blood component in enhancing bone healing and implant stability. A clinical study

Evaluation and comparison of the effects of antibiotics loaded A-PRF placed in extraction sockets on bone formation, implant stability and insertion torque in early implant placement at 8 Weeks - A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095998
Enrollment
36
Registered
2025-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K083- Retained dental root

Interventions

Intervention1: Amoxicillin/Clavulanic acid loaded A-PRF therapy: 0.5ml of 1.2gm Amoxicillin/clavulanic acid is loaded into A-PRF plug prepared from patient own blood. The plug is placed into the alve

Sponsors

Dr Putta Sri Lakshmi Prasanna Anjaneyulu
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anesthesiologists (ASA) -1 category 2.Bilateral or unilateral with one or more teeth advised for extraction in the premaxillary region. 3Non-restorable carious lesion 4.Root resorption, root caries and root fracture with questionable prognosis 5.Intact buccal cortical plate after extraction

Exclusion criteria

Exclusion criteria: 1.Patients subjected to radiotherapy in the head and neck. 2.Patients with poor compliance and smokers 3.Medical conditions or medications known to alter soft tissue or bone healing 4.Systemic infections 5.Roots extending into maxillary sinus 6.Dehiscence in buccal cortical plates after extraction 7.Patient on systemic antibiotics

Design outcomes

Primary

MeasureTime frame
histomorphometric analysisTimepoint: 2 months after extraction,while placing dental implant.

Secondary

MeasureTime frame
insertion torque.Timepoint: 2 months at the time of implant placement.;implant stabilityTimepoint: 0,1 and 3 months.

Countries

India

Contacts

Public ContactDr M Satyanarayana Raju

Vishnu Dental College.

satya@vdc.edu.in9492293809

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026