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To study and compare the effect of Ketamine to that of Dexmedetomidine in reducing the degree of Propofol injection pain.

Comparative analysis of pretreatment with dexmedetomidine v/s ketamine to alleviate the degree of propofol injection pain - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095946
Enrollment
104
Registered
2025-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: Ketamine: inj.ketamine 0.5mg/kg (Group K) diluted with normal saline loaded in 10ml syringe administered over 10mins prior to Propofol injection pain. Control Intervention1: Dexmedetomi

Sponsors

M S Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1/2 undergoing elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: CV disease and uncontrolled HTN, allergy to study drugs, hepatic/renal issues, pregnancy, psychiatric illness or problem in communication

Design outcomes

Primary

MeasureTime frame
To compare the degree of propofol injection pain between the two groups receiving ketamine v/s dexmedetomidine. Timepoint: over a 20sec duration during injection of Propofol—

Secondary

MeasureTime frame
To evaluate the hemodynamic changes like heart rate ,blood pressure, oxygen saturation following the pretreatment with ketamine v/s dexmedetomidine. Timepoint: At baseline, during infusion of Dexmedetomidine or Ketamine over 10mins, prior to adminstration of propofol.—

Countries

India

Contacts

Public ContactDr Leena H Parate

M S Ramaiah Medical College

dr_leenag@yahoo.co.in9480525925

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026