Comparison of effectiveness’s of letrozole with misoprostol versus mifepristone with Misoprostol in achieving complete abortions in first trimester among women aged 18-40 years a randomised controlled trial

Comparison of effectiveness of letrozole with misoprostol versus mifepristone with misoprostol in achieving complete abortions in first trimester among women aged 18 – 40 years – A Randomized controlled trial. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/095930

Enrollment

Registered

2025-10-13

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Tab.Letrozole 20mg: 20mg per Control Intervention1: Tab Mifepristone 200 mg: 200 mg per oral stat

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women with single live intrauterine pregnancy less than 12 weeks intended for medical abortion 2. No comorbidities 3. Not allergic to drug in usage 4. Willing for follow up

Exclusion criteria

Exclusion criteria: 1) Antenatal women belong to First trimester (1-12 weeks of gestation) and more than 32 weeks of gestation 2) Women with medical complications/ Hematological disorders 3) Women with Hemoglobinopathies 4) Liver disorder like jaundice, cirrhosis, or renal failure 5) Antenatal women with Hemoglobin level less than 7g%

Design outcomes

Primary

Measure	Time frame
To determine the addition of letrozole versus mifepristone with misoprostol in achieving complete abortion in first trimester among woman between age of 18-40 years.Timepoint: 72 hours	—

Secondary

Measure	Time frame
1. To evaluate number of abortions requiring instrumentation follow up. 2.To evaluate additional dose of Misoprostol required for complete abortion in both regimens. 3.To evaluate the blood loss in both regimens 4. To evaluate the adverse effects in both regimensTimepoint: 3 days;• To evaluate the induction to complete abortion time interval in both regimen • To evaluate the number of abortions requiring follow up instrumentation. • To evaluate the additional dose of misoprostol required for complete abortion in both regimens. • To estimate the amount of blood loss between both of the regimens by haemoglobin estimation. • To evaluate the adverse effects in both regimens.Timepoint: 72 hours	—

Measure

Time frame

1. To evaluate number of abortions requiring instrumentation follow up. 2.To evaluate additional dose of Misoprostol required for complete abortion in both regimens. 3.To evaluate the blood loss in both regimens 4. To evaluate the adverse effects in both regimensTimepoint: 3 days;• To evaluate the induction to complete abortion time interval in both regimen • To evaluate the number of abortions requiring follow up instrumentation. • To evaluate the additional dose of misoprostol required for complete abortion in both regimens. • To estimate the amount of blood loss between both of the regimens by haemoglobin estimation. • To evaluate the adverse effects in both regimens.Timepoint: 72 hours

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Countries

India

Contacts

Public ContactDr Deeksha B

Aarupadai Veedu Medical College and Hospita

p.ramya.dr@gmail.com9791246020

Outcome results