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Attenuation of laryngoscopic response in otorhinolaryngologic surgeries under general anaesthesia.

A prospective randomised single-blind observational study to assess the effect of IV dexmedetomidine vs. IV esmolol and lignocaine combination for attenuation of laryngoscopic response in patients undergoing otorhinolaryngologic surgeries under general anaesthesia. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095875
Enrollment
50
Registered
2025-10-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H758- Other specified disorders of middle ear and mastoid in diseases classified elsewhere

Interventions

Intervention1: IV dexmedetomidine: comparison of hemodynamic changes will be done while doing laryngoscopy both groups and evaluation of which group is better for attenuating the laryngoscopy response

Sponsors

GMERS medical college and hospital Gotri
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: BMI less than 30 kg/m2 ASA 1-2 Pulse rate equal to or above 70/min with regular rhythm

Exclusion criteria

Exclusion criteria: Patient Refusal Allergic to study drugs On chronic Medication for heart diseases like: AV Blocks, CHF, Brady-arrythmias, IHD, Hypertension. Laryngoscopy time more than 20 seconds Difficult bag and mask ventilation Difficult intubation

Design outcomes

Primary

MeasureTime frame
To evaluate Hemodynamic response that is pulse rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure & rate pressure product at baseline, 1 minute, 3 minutes & 5 minutes after laryngoscopyTimepoint: To evaluate pulse rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure & rate pressure product at baseline, 1 minute, 3 minutes and 5 minutes after laryngoscopy

Secondary

MeasureTime frame
To note any adverse effects associated with drugs used in both the groups, any rescue medication needed for correction of over-attenuation of the response, such as use of sympathomimetic drugsTimepoint: To note any adverse effects associated with drugs used in both the groups, any rescue medication needed for correction of over-attenuation of the response, such as use of sympathomimetic drugs till the first 5 minutes of laryngoscopy & intubation

Countries

India

Contacts

Public ContactDr Santosh Dubey

GMERS medical college and hospital, Gotri, Vadodara

santosh19692001@yahoo.com9825359853

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026