What s the Best Way to Use Lignocaine for Safer Tube Insertion During Surgery? A Comparison of Three Methods

Comparing The Hemodynamic Effects Of Ultrasound Guided Transtracheal Lignocaine, Intravenous Lignocaine, Nebulized Lignocaine During Endotracheal Intubation A Randomized Controlled Trial - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/095852

Enrollment

120

Registered

2025-10-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A(Transtracheal Lignocaine): Patients will receive ultrasound-guided transtracheal lignocaine (2 ml of 4 percentage of lignocaine) 3 minutes before intubation. Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA physical status 1,2 and 3 2. Patients scheduled for elective surgery under general anesthesia requiring endotracheal intubation 3. Modified Mallampati Class 1 or 2

Exclusion criteria

Exclusion criteria: 1. ASA physical status 3 or higher 2. Obese patients (BMI greater than 30) 3. Emergency surgery 4. Age less than 18 years or more than 60 years 5. Modified Mallampati Class 3 or 4 6. Known allergy to lignocaine 7. Patients with anticipated difficult airway 8. Duration of laryngoscopy exceeding 15 seconds 9. Anatomical abnormalities of the neck or anterior cervical region 10. Inability to identify the cricothyroid membrane on ultrasound

Design outcomes

Primary

Measure	Time frame
1.To evaluate and compare the effects on hemodynamic response associated with laryngoscopy and intubation in these three groups. 2.To assess the incidence of tachycardia or hypertension during and immediately after intubation as a measure of sympathetic stress response. Timepoint: 1.Baseline (before induction) 2.After induction (before administration of study drug) 3.At intubation (0 minute) 4.1, 3, 5 minutes after intubation	—

Measure

Time frame

1.To evaluate and compare the effects on hemodynamic response associated with laryngoscopy and intubation in these three groups. 2.To assess the incidence of tachycardia or hypertension during and immediately after intubation as a measure of sympathetic stress response. Timepoint: 1.Baseline (before induction) 2.After induction (before administration of study drug) 3.At intubation (0 minute) 4.1, 3, 5 minutes after intubation

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Stephen Anto S

Vinayaka Missions Medical College and Hospital

stephenantosuresh@gmail.com8248629177

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026