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Study comparing two types of pre surgery nebulization one with dexmedetomidine and the other with a combination of ketamine and dexmedetomidine to find which is better to prevent sore throat after laparoscopic surgery in adults

Comparison of Nebulization with Dexmedetomidine versus Ketamine-Dexmedetomidine combination for Post-Operative Sore Throat in adult patients undergoing laparoscopic surgery - A Randomised parallel arm study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095825
Enrollment
80
Registered
2025-10-09
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group 2:Nebulized Dexmedetomidine 1mcg/kg and Ketamine 0.5mg/kg diluted in 4 ml of normal saline.: On the day of surgery, Patients will be nebulized according to their assigned group a

Sponsors

Dr Ashutosh Kaushal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with American Society of Anesthesiologist (ASA) physical status grading I & II.

Exclusion criteria

Exclusion criteria: 1. Non consenting patients. 2. Allergy to dexmedetomidine or ketamine. 3.Current upper respiratory tract infections, pre-existing sore throat and/or hoarseness. 4.Patients using steroids or nonsteroidal anti-inflammatory drugs. 5.Patients with chronic obstructive pulmonary disease, asthma. 6.Pregnant patients. 7.Any history of difficult intubation, loose teeth. 8.Difficult intubation requiring more than one attempt. 9.Already intubated patients. 10.Patients not extubated at the end of surgery. 11.Patients with sinus bradycardia, atrioventricular block, cardiac disease.

Design outcomes

Primary

MeasureTime frame
Incidence of Postopertive sore throat (POST) between both the groups.Timepoint: 10 mins,6hrs,12hrs and 24hrs after extubation.—

Secondary

MeasureTime frame
To estimate and compare effect of nebulisation with dexmedetomidine and ketamine dexmedetomidine on heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP)and mean arterial pressure (MAP) at defined time point.Timepoint: 0 minute at induction,0 minute at intubation, 1 minute and 5 minutes after intubation;To estimate and compare effect of nebulisation with dexmedetomidine and ketamine-dexmedetomidine on patient sedation using Ramsay sedation score.Timepoint: 10 minutes,1hr,6hrs after extubation.—

Countries

India

Contacts

Public ContactDr Ashutosh Kaushal

All India Institute of Medical Sciences Bhopal

ashutosh.anaesth@aiimsbhopal.edu.in8765515521

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026