Randomised Control Trial to study if the use of albumin during hemodialysis leads to more fluid removal in children with Acute Kidney Injury having low serum albumin levels

Effect of priming the circuit with 5 percent albumin on ultrafiltration volume in hypoalbuminemic children with acute kidney injury undergoing hemodialysis: An open label randomized control trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/095819

Enrollment

Registered

2025-10-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N179- Acute kidney failure, unspecified

Interventions

Intervention1: 5% albumin: Priming will be done with 5% albumin in the beginning of hemodialysis in hypoalbuminemic children with acute kidney injury Control Intervention1: Not Applicable: Not Applica

Eligibility

Inclusion criteria

Inclusion criteria: Children with acute kidney injury according to KDIGO criteria with serum albumin levels less than 3 g/dl having any indication for hemodialysis

Exclusion criteria

Exclusion criteria: children allergic to albumin or having hemoglobin less than 10 g/dl or if the extracorporeal volume comes out to be greater than 10% of blood volume of the subject

Design outcomes

Primary

Measure	Time frame
Mean difference in net ultrafiltration volumes when priming is done with 5% albumin as compared to no priming in hypoalbuminemic children aged 1-18 years with AKI undergoing hemodialysis. Timepoint: 1 year	—

Secondary

Measure	Time frame
To compare the effect of priming with 5% albumin and no priming is done Number and duration of episodes of intradialytic hypotension Number and volume of saline bolus given (in the event of any hypotensive episode) Inferior Vena Cava Collapsibility index/Inferior Vena Cava Distensibility Index pre and post dialysis Post dialysis weight, BP, serum albumin levels within 30 minutes of dialysis session Timepoint: 1 year	—

Measure

Time frame

To compare the effect of priming with 5% albumin and no priming is done Number and duration of episodes of intradialytic hypotension Number and volume of saline bolus given (in the event of any hypotensive episode) Inferior Vena Cava Collapsibility index/Inferior Vena Cava Distensibility Index pre and post dialysis Post dialysis weight, BP, serum albumin levels within 30 minutes of dialysis session Timepoint: 1 year

—

Countries

India

Contacts

Public ContactDr Abhijeet Saha

Kalawati Saran Childrens Hospital, Lady Hardinge Mecial College

drabhijeetsaha@yahoo.com9711007064

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026