Health Condition 1: M96-M96- Intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified
Conditions
Interventions
Control Intervention1: Injection Neostigmine: 0.05mg/kg intravenous single dose after completion of surgery prior to extubation
Control Intervention2: Injection Sugammadex: 2mg/kg intravenous single d
Sponsors
Himalayan Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. American Society of Anaesthesiologist Physical Status I-III 2. Scheduled for a surgical procedure under general anaesthesia requiring endotracheal intubation 3. Anaesthesia induction with Vecuronium as NMBA
Exclusion criteria
Exclusion criteria: 1. Anticipation of a difficult airway 2. Known or suspected neuromuscular disorders, significant renal dysfunction, known or suspected family history of malignant hyperthermia, and allergies to narcotics, muscle relaxants, or other medications used during general anaesthesia 3. Patients receiving medication at a dose and/or time-point likely to interfere with NMBDs and in whom the use of Neostigmine and/or glycopyrrolate could be contraindicated 4. Those with diaphragm insufficiency or massive pleural effusion 5. Those undergoing upper abdominal laparotomy will be excluded after which we cannot obtain a satisfactory ultrasound imaging or do not have space for the placement of the ultrasound probe
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare postoperative Pulmonary function after neuromuscular blockade reversal associated with the use of Sugammadex and NeostigmineTimepoint: 10,30,60 and 120 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the residual neuromuscular blockade effect of Vecuronium after reversal with Sugammadex compared to Neostigmine up to 2 hours postoperatively.Timepoint: 10,30,60 and 120 minutes | — |
Countries
India
Contacts
Public ContactGurjeet Khurana
Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun
Outcome results
None listed