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A Study of Herpes Simplex Virus in Immune-Mediated Bullous (fluid filled)Disorders

A Study of Molecular and Serological Signatures of Herpes Simplex Virus in Autoimmune Blistering Disorders - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/10/095754
Enrollment
50
Registered
2025-10-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L109- Pemphigus, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Indian Association of Dermatologist,venerologist and leprologist
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria 1)Age more than 18 year 2)Patients with autoimmune blistering disorders (pemphigus group of disorders, sub-epidermal blistering disorders) Use of immunosuppressive medications such as corticosteroids, Azathioprine, Methotrexate, or biologics (e.g., Rituximab), which predispose the patient to secondary infections like HSV due to immune suppression.

Exclusion criteria

Exclusion criteria: 1) Patients less than 18 years with AIBD and HSV infection 2) Patients with CBDC 3) Patients with HSV infections in absence of AIBD 4) Pregnant and lactating mother 5) History of Trauma oral mucosa and over genitals 6) Other blistering disorders- genetic, metabolic, infective, drug induced etc GENETIC BLISTERING DIORDER Epidermolysis Bullosa (EB) Pemphigus group of disorder Bullous Congenital Ichthyosiform Erythroderma (BCIE) Hereditary Epidermolytic Hyperkeratosis Infective blistering disorder Varicella (Chickenpox) Bullous Impetigo(BI) Hand, Foot, and Mouth Disease(HFMD) Staphylococcal Scalded Skin Syndrome (SSS) Herpes Zoster (Shingles) Metabolic blistering disorder Porphyria Cutanea Tarda (PCT) Erythropoietic Protoporphyria (EPP) Niemann-Pick Disease(NPD) Glycogen Storage Diseases (GSD) Lipid Metabolism Disorders Smith-Lemli-Opitz Syndrome (SLOS) Rothmund-Thomson Syndrome Disorders of Copper Metabolism (Wilson s disease)

Design outcomes

Primary

MeasureTime frame
1)To estimate the prevalence of Herpes simplex virus in autoimmune blistering disordersTimepoint: single-visit study,at day 0—

Secondary

MeasureTime frame
1) To estimate the severity of AIBD at the time of enrolment in patients infected with herpes simplex. 2) To estimate whether new HSV infection/reactivation correlates with the disease flare in AIBD. Timepoint: single visit study, day 0—

Countries

India

Contacts

Public ContactDr Niranjan kamath hosdurg

GCS Medical College and research centre

dr.jignapadhiyar@gmail.com7550170661

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026