Skip to content

Calculating minimum effective dose of local anaesthetic mixture for arm surgeries using nerve block

Minimum effective volume of 0.5 percent Ropivacaine and 2 percent Lignocaine mixture for ultrasound guided Retroclavicular Brachial Plexus Block: A Prospective Dose Finding Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095722
Enrollment
25
Registered
2025-10-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ropivacaine and Lignocaine mixture: 0.5% Ropivacaine and 2% Lignocaine mixture in 3:2 ratio given at the time of block after taking the patient in the operation theatre. around 24 hours

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical Status I or II, Consent for regional anaesthesia and participation, Elective surgery of the upper limb, BMI between 18 30 kg/m

Exclusion criteria

Exclusion criteria: coagulopathy, allergy to local anaesthetics, pregnancy, pre existing neuropathy

Design outcomes

Primary

MeasureTime frame
The calculation of minimum effective volume (MEV50 and MEV95) of a mixture of 0.5% ropivacaine and 2% lignocaine for achieving a successful sensory and motor block at 30 minutes.Timepoint: The calculation of minimum effective volume (MEV50 and MEV95) of a mixture of 0.5% ropivacaine and 2% lignocaine for achieving a successful sensory and motor block at 30 minutes.

Secondary

MeasureTime frame
1. Block performance time (time from the first insertion of the blocking needle to its removal) 2. Block onset time ( time required for a composite score of 14 points) 3. Duration of sensory (time from the injection of LA to the time the patient recovers full sensation of the upper limb) 4. Duration of motor blockade (time from injection of LA to the time the patient recovers full function of the arm) 5. Any perioperative complications (e.g., local anesthetic systemic toxicity, vascular puncture) 6. Need for conversion to GA Timepoint: from start of anaesthesia till 24 hours postoperatively

Countries

India

Contacts

Public ContactHeena Garg

AIIMS, New Delhi

gargheena11@gmail.com9464533877

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026