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Two drug combination vs one drug for prevention of vomiting after operation

Comparison of ondansetron-olanzapine combination with ondansetron alone for PONV prophylaxis in patients scheduled for laparoscopic cholecystectomy: A Randomized Controlled Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095654
Enrollment
102
Registered
2025-10-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Antiemetic agent will be given: Drug will be given once, 2 h before anaesthesia and 30 min before extubation Control Intervention1: olanz

Sponsors

University college of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II, undergoing laparoscopic cholecystectomy for gall stone disease under GA

Exclusion criteria

Exclusion criteria: .Pregnant patients .Patients having cardiac, hepatic or renal disease .Patients with history of psychiatric disorder or currently on olanzapine .Allergic to any drug used in study .Long term use of long acting antiemetics, emetogenic drugs, opioids, glucocorticoids or cancer chemotherapy.

Design outcomes

Primary

MeasureTime frame
Incidence of PONV in the initial 24 hrs after surgeryTimepoint: Incidence of PONV in the initial 24 hrs after surgery—

Secondary

MeasureTime frame
1.Severity of PONV in the first 24 hr 2.Total requirement of rescue antiemetic in the first 24 hr Timepoint: 0-2hrs, 2-6hrs, 6-12hrs, 12-24hrs—

Countries

India

Contacts

Public ContactHimani

UCMS and GTB Hospital

rsramb@yahoo.co.in9868399699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026