Comparative evaluation of two different doses of oral pregabalin given before surgery on duration of spinal anesthesia and reduction of postoperative pain.

A randomized controlled trial to compare the efficacy of two different doses of pre emptive oral pregabalin on prolongation of spinal anesthesia and attenuation of postoperative pain - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/10/095602

Enrollment

Registered

2025-10-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Pregabalin 150mg: PREGABALIN 150MG WILL BE GIVEN 90 MIN PRE OPERATIVELY. Control Intervention1: PREGABALIN 75MG: PREGABALIN 75MG WILL BE GIVEN 90 MIN PRE OPERATIVELY

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA 1 and 2 2.patient scheduled for elective lower abdominal and lower limb surgeries 3.BMI 18 to 35 kg/m2

Exclusion criteria

Exclusion criteria: 1.Allergy to pregabalin 2.contraindication to spinal anesthesia, 3.Renal/hepatic dysfunction 4.chronic analgesic use 5.refusal to participate.

Design outcomes

Primary

Measure	Time frame
1. Duration of sensory block (onset to regression to S1 dermatome). 2. Duration of motor block (onset to Bromage score 0). 3. Time to first rescue analgesic (minutes from block administration to first analgesic request). 4. Total opioid requirement within 24 hours (tramadol and paracetamol equivalents). 5. Pain intensity using the Visual Analogue Scale (VAS). 6. Side effects (nausea, vomiting, dizziness, sedation, respiratory depression).Timepoint: 1. Duration of sensory block (onset to regression to S1 dermatome). 2. Duration of motor block (onset to Bromage score 0). 3. Time to first rescue analgesic (minutes from block administration to first analgesic request). 4. Total opioid requirement within 24 hours (tramadol and paracetamol equivalents). 5. Pain intensity using the Visual Analogue Scale (VAS). 6. Side effects (nausea, vomiting, dizziness, sedation, respiratory depression).	—

Measure

Time frame

1. Duration of sensory block (onset to regression to S1 dermatome). 2. Duration of motor block (onset to Bromage score 0). 3. Time to first rescue analgesic (minutes from block administration to first analgesic request). 4. Total opioid requirement within 24 hours (tramadol and paracetamol equivalents). 5. Pain intensity using the Visual Analogue Scale (VAS). 6. Side effects (nausea, vomiting, dizziness, sedation, respiratory depression).Timepoint: 1. Duration of sensory block (onset to regression to S1 dermatome). 2. Duration of motor block (onset to Bromage score 0). 3. Time to first rescue analgesic (minutes from block administration to first analgesic request). 4. Total opioid requirement within 24 hours (tramadol and paracetamol equivalents). 5. Pain intensity using the Visual Analogue Scale (VAS). 6. Side effects (nausea, vomiting, dizziness, sedation, respiratory depression).

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactPRABHA P

SAPTHAGIRI INSTITUTE OF MEDICAL SCIENCE AND RESEARCH CENTRE

prabhap1510@gmail.com9448055973

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026