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Saliva and Blood Tests for Gum Disease: Before and After Treatment

EVALUATION OF SALIVARY AND SERUM INTERLEUKIN -38 AND THROMBOMODULIN LEVELS IN PERIODONTITIS PATIENTS BEFORE AND AFTER NON-SURGICAL PERIODONTAL THERAPY: A CLINICAL AND BIOCHEMICAL STUDY - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/10/095587
Enrollment
49
Registered
2025-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Non-Surgical Periodontal Therapy: All participants will receive non-surgical periodontal therapy (scaling and root planing) with oral hygiene instructions. Saliva and blood samples will

Sponsors

Dr Supriti Brahma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age- 21 to 60 years of age Both males and females

Exclusion criteria

Exclusion criteria: 1. Individuals with systemic illness 2. Pregnant & lactating women 3. History of medications such as antibiotics or anticoagulant therapy for past 6 months 4. Participants with previous periodontal treatment or periodontal surgery for past 6 months 5. Smokers

Design outcomes

Primary

MeasureTime frame
Change in IL-38 and thrombomodulin concentrations (saliva and serum) measured by ELISA.Timepoint: Change in IL-38 and thrombomodulin concentrations (saliva and serum) measured by ELISA.At baseline and 4 weeks after treatmnet—

Secondary

MeasureTime frame
Clinical periodontal parameters (measured by calibrated examiner): Mean probing depth (PD), mean clinical attachment level (CAL), and bleeding on probing (BOP %).Timepoint: Time points: Baseline (T0) and 3 months (T1).—

Countries

India

Contacts

Public ContactDr Supriti Brahma

Department of Periodontology, Room no- 106, SRM Kattankulathur Dental College

saravana4@srmist.edu.in9944361464

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026