Health Condition 1: N183- Chronic kidney disease, stage 3 (moderate) Health Condition 2: N184- Chronic kidney disease, stage 4 (severe) Health Condition 3: N185- Chronic kidney disease, stage 5
Conditions
Interventions
Intervention1: Oral Sodium bicarbonate: Sodamint 300 mg will be administered to the patients with a dose of 0.5 mEq per kg of their lean body weight per day in the higher bicarbonate target group wher
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Adults more than 18 years of age Participants with serum bicarbonate less than 18 millimol per litre, with or without oral bicarbonate supplementation OR patients with serum bicarbonate less than 20 millimol per litre and are on oral sodium bicarbonate at screening. CKD patients stage 3 to 5.
Exclusion criteria
Exclusion criteria: Patients who are on dialysis or with a history of transplantation. History of advanced heart failure (NYHA Class III and IV) or significant left ventricular dysfunction (ejection fraction less than 40 percent) Patients with structural and functional anomalies of the gastrointestinal tract, chronic liver disease, active malignancies, and chronic infections. Uncontrolled hypertension more than 160/100 mmHg. Morbid obesity (BMI more than or equal to 40 kg per m ). Pregnant and lactating women. Patients who refuse to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in estimated glomerular filtration rate between the groups.Timepoint: 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in muscle mass and muscle strengthTimepoint: 1 year;Changes in blood pressure, volume overload and hyperkalemiaTimepoint: 1 year;Nutritional statusTimepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Indu Ramachandra Rao
Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal
Outcome results
None listed