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Study on Treatment Outcomes and Use of Next-Generation Gene Testing in Patients with Malignant Peritoneal Mesothelioma: A retrospective

Retrospective analysis of clinical outcome and clinical next-generation sequencing application in malignant peritoneal mesothelioma patients treated in a tertiary cancer care center in India - COMET study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/10/095523
Enrollment
70
Registered
2025-10-01
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C457- Mesothelioma of other sites

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil

Sponsors

Tata Memorial Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 70 years at the time of diagnosis. 2. Histopathological confirmation of malignant peritoneal mesothelioma. 3. Receipt of treatment/ treatment plan (systemic chemotherapy, surgery, or both) from TMH, Parel

Exclusion criteria

Exclusion criteria: 1. Patients who were diagnosed at TMH but received treatment elsewhere. 2. Incomplete clinical records. 3. Availability of formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks at TMH for genomic analysis is not compulsory.

Design outcomes

Primary

MeasureTime frame
To study the overall survival of the peritoneal mesothelioma.Timepoint: date of diagnosis till date of death: baseline till patient date of death—

Secondary

MeasureTime frame
To study the progression-free survival of peritoneal mesothelioma patients. Timepoint: baseline till PD;Baseline demographic characteristics of peritoneal mesothelioma patients.Timepoint: basline;Molecular Characterization Analysis by NGS.Timepoint: Baseline—

Countries

India

Contacts

Public ContactPrabhat Ghanshyam Bhargava

Tata Memorial Hospital

doctor.dharmpal32@gmail.com7878530692

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026