Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: This group will receive intranasal(through nose) dexmedetomidine of total dose of 1 microgram per kg body weight(1 g/kg) only once 30 minutes before extubation. Durati
Sponsors
All India Institute Of Medical Sciences ,New Delhi
Department of Anaesthesiology Pain Medicine and Critical Care
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with controlled hypertension on anti hypertensive medications. 2. Patients scheduled for elective laparoscopic cholecystectomy under general anaesthesia. 3. Patients falling under ASA- II,III category.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to dexmedetomidine. 2. Patients having severe cardiac conduction abnormalities. 3. Patients on chronic sedatives or opioid use. 4. Patients having nasal pathology preventing intranasal drug delivery 5. Patients with heart rate less than 60 beats per minute.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in mean blood pressure from baseline at the time of extubationTimepoint: 0, 1, 2, 3, 5, 10,15 minutes after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in heart rate(HR), systolic blood pressure(SBP) and diastolic blood pressure( DBP) from baseline at the time and after extubationTimepoint: 0, 1, 2, 3, 5, 10,15 minutes after extubation;Sedation Score (Ramsay Sedation Score)Timepoint: 15, 30, 60 minutes after extubation;Visual Analogue Scale (VAS) pain scoreTimepoint: 15, 30, 60 minutes after extubation;Incidence of adverse events ( for example bradycardia, hypotension, nausea, vomiting, delayed emergence)Timepoint: 2 hours post operatively | — |
Countries
India
Contacts
Public ContactKartik Saini
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed