Comparison of mannitol with normal saline in voluntary kidney donor on kidney function in kidney recipient.

Comparison of effect of mannitol administration v/s normal saline before renal artery cross clamp during donor nephrectomy on time to normalization of creatinine. A randomized controlled equivalent trial study. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095510

Enrollment

Registered

2025-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Normal Saline : 100 ml of 0.9 % saline: Route of administration: Intravenous Timing : 15 minutes before donor kidney vascular crossclamp over 15 minutes Control Intervention1: Intraveno

Eligibility

Inclusion criteria

Inclusion criteria: Live kidney donors between 18 and 65 years of age.

Exclusion criteria

Exclusion criteria: Known allergy to mannitol Deceased renal transplantation Combined transplantation Patients undergoing dialysis within 6hrs of transplant

Design outcomes

Primary

Measure	Time frame
Days taken for the normalization of creatinine in kidney transplant recipientsTimepoint: Serum creatine measurement up to 7 days or till normalization of creatine values	—

Secondary

Measure	Time frame
Incidence of delayed graft functionTimepoint: posteoperative 1 week;Creatinine elimination ratio Timepoint: postoperative 24 hours, 48 hours, 72 hours;Length of stay in hospital for donor and recipient Timepoint: At the day of discharge;urinary outputTimepoint: postoperative 24 hours, 48 hours, 72 hours;GFR using dynamic creatine clearance methodTimepoint: postoperative 24 hours, 48 hours, 72 hours	—

Measure

Time frame

Incidence of delayed graft functionTimepoint: posteoperative 1 week;Creatinine elimination ratio Timepoint: postoperative 24 hours, 48 hours, 72 hours;Length of stay in hospital for donor and recipient Timepoint: At the day of discharge;urinary outputTimepoint: postoperative 24 hours, 48 hours, 72 hours;GFR using dynamic creatine clearance methodTimepoint: postoperative 24 hours, 48 hours, 72 hours

—

Countries

India

Contacts

Public Contactkamal kajal

Postgraduate Institute of medical education and research, Chandigarh

kamal.kajal@gmail.com9560412726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026