Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Probiotics + Standard treatment (Hair transplant/medications: Will receive the same standard therapy as comparator group, along with a daily oral probiotic capsule for 16 weeks. The pro
Sponsors
All India Institute Of Medical Sciences Delhi Thesis grant
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged 18 to 50 years with clinically diagnosed AGA (Hamilton Norwood scale for men, Ludwig scale for women). No antibiotic or probiotic use in the past month. Willingness to provide stool samples and adhere to study protocols.
Exclusion criteria
Exclusion criteria: Presence of other forms of alopecia (e.g., alopecia areata). Gastrointestinal disorders or systemic inflammatory conditions. Immunocompromised status or use of immunosuppressive medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in hair density measured objectively via standardized trichoscopic imaging and quantified using validated software-based analysis. Timepoint: 0,4 weeks,8 weeks,12 weeks and 16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient-reported outcomes on hair satisfaction and quality of life using Validated Questionnaire Assessment of gut microbiota composition through 16S rRNA sequencing of stool samples before the start of treatment and at 16 weeks after initiation of probiotic treatment. Bacterial 16S rRNA gene sequences (V3 V4 regions) will be amplified from the whole genome using the primers, 341F and 805R and amplicon libraries will be sequenced on an Illumina NovaSeq platform. Evaluation of systemic inflammatory markers and hormonal profiles Timepoint: 0, 16 weeks | — |
Countries
India
Contacts
Public ContactDr Maneesh Singhal
AIIMS,Delhi
Outcome results
None listed