Effect of carbohydrate drink versus plain water on stress during head and neck cancer surgery

Comparison of carbohydrate containing clear fluid versus plain water on perioperative surgical stress in elective head and neck oncological surgeries: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095484

Enrollment

Registered

2025-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ingestion of Carbohydrate containing clear fluid until 2 hours before surgery: To compare level of Serum cortisol as a measure of perioperative stress at four time points: 8 PM a day be

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective head and neck cancer surgery ECOG status: 1 and 2 BMI: 18.5-30 kg/m2 Surgical duration less than 5hrs

Exclusion criteria

Exclusion criteria: Patient with advance cardio-pulmonary compromise (NYHA class 4) Free flap Major blood loss during surgery- more than maximum allowable blood loss (MABL) i.e.65 ml/kg of ideal body weight. Patients receiving medications known to interfere with hormonal response to stress (e.g. Beta blockers, steroids etc) Coexisting conditions likely to delay gastric emptying like morbid obesity, diabetes, hiatus hernia, gastroparesis, previous gastric surgery (for example, gastric bypass), gastroesophageal reflux disease, enteral feeding, drugs which alter the gastric motility, pregnancy, hypothyroidism, chronic kidney disease

Design outcomes

Primary

Measure	Time frame
To compare levels of Serum cortisol at four time points as a measure of perioperative stress in the two group i.e. those drinking carbohydrate containing clear fluid versus those drinking plain waterTimepoint: At four timepoints: 8 PM a day before surgery, 8 AM on the day of surgery, and at 2 hours and 24 hours after surgical incision	—

Secondary

Measure	Time frame
To compare levels of C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) at four time points as a measure of perioperative stress in the two group i.e. those drinking carbohydrate-containing clear fluid versus those drinking plain waterTimepoint: At four timepoints: 8 PM a day before surgery, 8 AM on the day of surgery, and at 2 hours and 24 hours after surgical incision;To compare inferior vena cava collapsibility index (IVCCI) in between the two groupsTimepoint: 2 hours after ingestion of carbohydrate containing fluid and plain water;To compare gastric residual volume (GRV) measured by USG in between the two groups Timepoint: 2 hours after ingestion of carbohydrate containing fluid and plain water	—

Measure

Time frame

To compare levels of C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) at four time points as a measure of perioperative stress in the two group i.e. those drinking carbohydrate-containing clear fluid versus those drinking plain waterTimepoint: At four timepoints: 8 PM a day before surgery, 8 AM on the day of surgery, and at 2 hours and 24 hours after surgical incision;To compare inferior vena cava collapsibility index (IVCCI) in between the two groupsTimepoint: 2 hours after ingestion of carbohydrate containing fluid and plain water;To compare gastric residual volume (GRV) measured by USG in between the two groups Timepoint: 2 hours after ingestion of carbohydrate containing fluid and plain water

—

Countries

India

Contacts

Public ContactAkshitha N Swamy

AIIMS BHOPAL

Anuj.Jain.MLN@gmail.com9755702644

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026