Role of intravenous magnesium and vitamin C in reducing severity of pain in the immediate postoperative period

Efficacy of intraoperative magnesium and vitamin C in the reduction of severity of pain in immediate postoperative period - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095467

Enrollment

Registered

2025-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M899- Disorder of bone, unspecified Health Condition 2: M974- Periprosthetic fracture around internal prosthetic elbow joint Health Condition 3: M979- Periprosthetic fracture around unspecified internal prosthetic joint Health Condition 4: M668- Spontaneous rupture of other tendons

Interventions

Intervention1: Intravenous magnesium and intravenous vitamin C: Post intubation 3 grams of intravenous vitamin C in 100 ml NS and 2 grams of intravenous magnesium sulphate in 100 ml NS over 30 minutes

Eligibility

Inclusion criteria

Inclusion criteria: Patients on agr group 18 to 60 years of either sex belonging to ASA I and II will be included in study who will undergo upper limb orthopedic surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Unwillingness of patient to participate in study, history of chronic pain, opioid or analgesic abuse, Cardiovascular disease, respiratory, neuromuscular, renal and hepatic disease, anaemia, dyselectrolytemia and massive blood loss, major oncosurgeries, duration of surgery more than 3 hours, pregnant and lactating women, previous history of allergy to study drug

Design outcomes

Primary

Measure	Time frame
Severity of postoperative pain as measured on VAS scale (0-10) in immediate postoperative period at 0 hour (in recovery room) followed by at every 10 minutes over the next 3 hoursTimepoint: Severity of postoperative pain as measured on VAS scale (0-10) in immediate postoperative period at 0 hour (in recovery room )followed by at every 10 minutes over the next 3 hours	—

Secondary

Measure	Time frame
Time to request for first dose of rescue analgesia(I.V Tramadol 1 mg/kg) over 3 hours in recovery room Time interval after administration of study drug to time to request for 1st dose of rescue analgesia. Total dose of analgesia after 1st requirement with a lock out interval of 10 minutes (I.V Tramadol 0.25 mg/kg with maximum dose of 1 mg/kg) over next 3 hours Timepoint: Time to request for first dose of rescue analgesia(I.V Tramadol 1 mg/kg) over 3 hours in recovery room Time interval after administration of study drug to time to request for 1st dose of rescue analgesia. Total dose of analgesia after 1st requirement with a lock out interval of 10 minutes (I.V Tramadol 0.25 mg/kg with maximum dose of 1 mg/kg) over next 3 hours	—

Measure

Time frame

Time to request for first dose of rescue analgesia(I.V Tramadol 1 mg/kg) over 3 hours in recovery room Time interval after administration of study drug to time to request for 1st dose of rescue analgesia. Total dose of analgesia after 1st requirement with a lock out interval of 10 minutes (I.V Tramadol 0.25 mg/kg with maximum dose of 1 mg/kg) over next 3 hours Timepoint: Time to request for first dose of rescue analgesia(I.V Tramadol 1 mg/kg) over 3 hours in recovery room Time interval after administration of study drug to time to request for 1st dose of rescue analgesia. Total dose of analgesia after 1st requirement with a lock out interval of 10 minutes (I.V Tramadol 0.25 mg/kg with maximum dose of 1 mg/kg) over next 3 hours

—

Countries

India

Contacts

Public ContactDr Rajmala Jaiswal

Pt BD Sharma University of Health Sciences Rohtak

aggarwal.priyanka93@gmail.com08607920759

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026